Jackson Carrion

Welcome

Hi, i'm Jackson Carrion, a PhD student in Computational & Systems Biology at MIT. In the Davis Lab, we develop and apply novel cryo-EM techniques, with a focus on tomograpghy and time-resolved methods, to better explore protein structure and dynamics in situ.

About

I completed my undergraduate and master's degrees at Arizona State University (ASU Biomedical Informatics) in Petra Fromme's lab, where I focused on developing new protein microcrystallization and XFEL methods to better study protein dynamics at femtosecond time-scales. Specifically proteins responsible for conducting photosythesis like Photosystem I/II, ATP synthase, Phycocyanin, etc. Eager to escape the heat, I joined the MIT Computational & Systems Biology Program. In the Davis lab, I am now passionate about developing and applying new cryo-EM methods for in-situ and time-resolved studies on various macromolecules to better explore the metadynamics of protein complexes at the atomic level.

Publications

2025

Resolving structural dynamics in situ through cryogenic electron tomography
Carrion J, Davis J. (2025). Resolving structural dynamics in situ through cryogenic electron tomography. (Currently under review with COSB). arXiv preprint

2024

CryoJAM: Automating Protein Homolog Fitting in Medium Resolution Cryo-EM Density Maps
Carrion J, Manjrekar M, Mikulevica A. (2024). CryoJam: Automating Protein Homolog Fitting in Medium Resolution Cryo-EM Density Maps. bioRxiv [Preprint]. 2024 Jul 10:2024.07.10:602952. doi: 10.1101/2024.07.10.602952. https://doi.org/10.1101/2024.07.10.602952 [code]

2023

Modular Droplet Injector for Sample Conservation Providing New Structural Insight for the Conformational Heterogeneity in the Disease-Associated NQO1 Enzyme
Doppler D, Sonker M, Egatz-Gomez A, Grieco A, Zaare S, Jernigan R, Meza-Aguilar J, Rabbani T, Manna A, Alvarez R. C, Karpos K, Cruz Villarreal J, Nelson G, Yang J, Carrion J, Morin K, Ketawala G. K, Pey A. L, Ruiz-Fresneda M. A, Pacheco-Garcia L. J, Hermoso A. J, Nazari R, Sierra R, Hunter M, Batyuk A, Kupitz C, Sublett R, Lisova S, Mariani V, Boutet S, Fromme R, Grant T, Botha S, Fromme P, Kirian R, Garcia-Martin M. J, Ros A. (2023). Modular droplet injector for sample conservation providing new structural insight for the conformational heterogeneity in the disease-associated NQO1 enzyme. Lab Chip, 23(13), 3016–3033. https://doi.org/10.1039/d3lc00176h

A Data-fusion Approach for Diagnosing Developmental Dyslexia with Multi-omics Datasets
Carrion J, Nandakumar R, Shi X, Gu H, Kim Y, Raskind W. H, Peter B, Dinu V. (2023). A data-fusion approach to identifying developmental dyslexia from multi-omics datasets. bioRxiv [Preprint]. 2023 Feb 27:2023.02.27.530280. doi: 10.1101/2023.02.27.530280. PMID: 36909570; PMCID: PMC10002702. https://doi.org/10.1101/2023.02.27.530280 [code]

Conferences

Time-resolved X-ray emission spectroscopy and serial femtosecond crystallography studies on the transient S4 state in Photosystem II
Carrion J, Mazalova V, Botha B, Yang J, Fromme P.
32nd Western Photosynthesis Conference (2023) [poster] [code]

Towards Structure Determination of the of the Photosynthetic Supercomplex to understand the Regulation of sustained Cyclic Electron Flow (CEF) in the photopsychrophile Chlamydomonas sp. UWO241
Yang J, Carrion J, Fromme P.
The Protein Society Annual Symposium (2022) [poster]

PolypNET: Lightweight UNET++ Architecture Capable of Identifying and Segmenting Cancerous Polyps From Colonoscopy Images
Carrion J, Graffin S. Anderson D.
Arizona State University Health Solutions Graduate Expo (2022) [Invited Talk] [code]

Awards

Lab on a Chip HOT Articles of 2023 – 11/2023
32nd Western Photosynthesis Conference Travel Award – 01/2023
ASU GPSA Individual Travel Grant – 05/2022
ASU GRSP Research Grant – 01/2022

CV

Download my CV

Contact

Please feel free to reach out to my email (jcarrion@mit.edu) if you have any questions or would like to chat!
Links to my social media accounts: X/Twitter | LinkedIn | GitHub | Google Scholar